Free cheat sheet lays out the best-performing Amazon PPC setups for Q4 2025

A comprehensive Amazon pay-per-click reference covering the most profitable campaign setups for the 2025 fourth quarter has been made publicly available after years as an internal document at a leading advertising agency that ranks among the platform's largest ad spenders.

The reference separates campaigns into the best-performing structures across Sponsored Products, Sponsored Brands and Sponsored Display. For each campaign type it explains the purpose, then walks through every setup field step by step: bidding strategy, targeting, bids, negative keywords and creative.

Each setup also comes with a video walkthrough showing how to build the campaign inside the Seller Central advertising console, plus a second video covering how to optimize it over time.

The strategies included reflect what is working right now, among them audience targeting, keyword theme targeting and product-targeted video ads. A single-sheet campaign tree and naming framework accompanies the guide, laying out every possible campaign setup in one place with a naming convention that keeps large accounts searchable.

The guide's release gives smaller sellers a structured framework for building their campaigns before fourth-quarter sales kick into gear, a period when advertising mistakes are at their most expensive.